Corsantrum Technology

Pomcad (Pomalidomide 2mg) Capsule

PRODUCT INTRODUCTION

Pomcad 2mg Capsule is used in the treatment of multiple myeloma and is used in combination with some other medicine (dexamethasone). It works by helping the bone marrow to produce normal blood cells and by killing abnormal cells.

Pomcad 2mg Capsule can be taken with or without food, but better to take it at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include fatigue, fever, bone pain, muscle cramp, and diarrhea. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.

Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. It makes your skin more sensitive towards sunlight, take caution while stepping out or wear protective clothing.

USES OF POMCAD CAPSULE

• Multiple myeloma

BENEFITS OF POMCAD CAPSULE

In Multiple myeloma

If you have multiple myeloma, your body is destroying bone faster than it is being replaced. This makes bones weak and painful and more likely to break. Pomcad 2mg Capsule may be prescribed along with other medicines. It is an important part of your treatment and increases the survival rate of people with multiple myeloma. This medicine will kill the abnormal cells and prevent their further growth as well as spread to other parts of the body. Follow your doctor’s instructions carefully to get the most benefit. Supplements of calcium and Vitamin D3 are also effective and may be prescribed if you do not have high blood calcium levels.

SIDE EFFECTS OF POMCAD CAPSULE

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Pomcad

• Fatigue

• Fever

• Bone pain

• Muscle cramp

• Diarrhea

• Nausea

• Constipation

• Breathing problems

• Cough

• Decreased appetite

• Decreased white blood cell count (neutrophils)

• Low blood platelets

• Decreased white blood cell count (lymphocytes)

• Anemia (low number of red blood cells)

HOW TO USE POMCAD CAPSULE

Take this medicine in the dose and duration as advised by your doctor. Pomcad 2mg Capsule may be taken with or without food, but it is better to take it at a fixed time.

HOW POMCAD CAPSULE WORKS

Pomcad 2mg Capsule is in a class of medications called immunomodulatory agents. It works by helping the bone marrow to produce normal blood cells and by killing abnormal cells in the bone marrow.

PRODUCT INTRODUCTION

Bdpoma 1mg Capsule is used in the treatment of multiple myeloma and is used in combination with some other medicine (dexamethasone). It works by helping the bone marrow to produce normal blood cells and by killing abnormal cells.

Bdpoma 1mg Capsule can be taken with or without food, but better to take it at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include fatigue, fever, bone pain, muscle cramp, and diarrhea. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.

Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. It makes your skin more sensitive towards sunlight, take caution while stepping out or wear protective clothing.

USES OF BDPOMA CAPSULE

• Multiple myeloma

BENEFITS OF BDPOMA CAPSULE

In Multiple myeloma

If you have multiple myeloma, your body is destroying bone faster than it is being replaced. This makes bones weak and painful and more likely to break. Bdpoma 1mg Capsule may be prescribed along with other medicines. It is an important part of your treatment and increases the survival rate of people with multiple myeloma. This medicine will kill the abnormal cells and prevent their further growth as well as spread to other parts of the body. Follow your doctor’s instructions carefully to get the most benefit. Supplements of calcium and Vitamin D3 are also effective and may be prescribed if you do not have high blood calcium levels.

SIDE EFFECTS OF BDPOMA CAPSULE

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Bdpoma

• Fatigue

• Fever

• Bone pain

• Muscle cramp

• Diarrhea

• Nausea

• Constipation

• Breathing problems

• Cough

• Decreased appetite

• Decreased white blood cell count (neutrophils)

• Low blood platelets

• Decreased white blood cell count (lymphocytes)

• Anemia (low number of red blood cells)

HOW TO USE BDPOMA CAPSULE

Take this medicine in the dose and duration as advised by your doctor. Bdpoma 1mg Capsule may be taken with or without food, but it is better to take it at a fixed time.

HOW BDPOMA CAPSULE WORKS

Bdpoma 1mg Capsule is in a class of medications called immunomodulatory agents. It works by helping the bone marrow to produce normal blood cells and by killing abnormal cells in the bone marrow.

Introduction :

Bortenat 3.5 Mg Injection is used in the treatment of multiple myeloma. By halting or reducing the growth of cancer cells, it demonstrates its effectiveness.

Bortenat 3.5 Mg Injection is given as an injection by a qualified medical professional. Your doctor will determine the appropriate dosage and frequency of administration for you. This is based on the condition you are being treated for and is subject to change. You should follow your doctor's instructions to the letter. It can have potentially dangerous negative effects if taken improperly or in excess. The benefits might not become apparent to you for a few weeks or months, but you shouldn't stop taking it until your doctor instructs you to.

Fatigue, nausea, and fever are some common side effects of this medicine. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Hence, inform your doctor if you notice fever, chills, joint or muscle pain, flushing or swelling of the face,  and chest pain. You are advised to drink plenty of fluids while taking this medicine.

Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.


Uses :

Multiple myeloma


Benefits :

In Multiple myeloma :

When you have multiple myeloma, your body breaks down bone more quickly than it replaces it. As a result, bones become fragile, painful, and more prone to breaking. Along with other cancer treatments like chemotherapy, Bortenat 3.5 Mg injection may be administered. It improves multiple myeloma patients' chances of survival and is a crucial component of your treatment. This medication will eliminate the malignant cells, stop their growth, and stop them from spreading to other body regions. To reap the greatest benefits, please adhere to your doctor's directions. If your blood calcium levels are not high, your doctor can advise you to take calcium and vitamin D3 supplements, both of which are beneficial.


Side Effects :

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.

Common side effects of Bortenat :

• Fatigue
• Anemia (low number of red blood cells)
• Nausea
• Low blood platelets
• Fever

Introduction :

Bortenat 2 Mg Injection is used in the treatment of multiple myeloma. By halting or reducing the growth of cancer cells, it demonstrates its effectiveness.

Bortenat 2 Mg Injection is given as an injection by a qualified medical professional. Your doctor will determine the appropriate dosage and frequency of administration for you. This is based on the condition you are being treated for and is subject to change. You should follow your doctor's instructions to the letter. It can have potentially dangerous negative effects if taken improperly or in excess. The benefits might not become apparent to you for a few weeks or months, but you shouldn't stop taking it until your doctor instructs you to.

Fatigue, nausea, and fever are some common side effects of this medicine. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Hence, inform your doctor if you notice fever, chills, joint or muscle pain, flushing or swelling of the face,  and chest pain. You are advised to drink plenty of fluids while taking this medicine.

Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.


Uses :

Multiple myeloma


Benefits :

In Multiple myeloma :

When you have multiple myeloma, your body breaks down bone more quickly than it replaces it. As a result, bones become fragile, painful, and more prone to breaking. Along with other cancer treatments like chemotherapy, Bortenat 2 Mg injection may be administered. It improves multiple myeloma patients' chances of survival and is a crucial component of your treatment. This medication will eliminate the malignant cells, stop their growth, and stop them from spreading to other body regions. To reap the greatest benefits, please adhere to your doctor's directions. If your blood calcium levels are not high, your doctor can advise you to take calcium and vitamin D3 supplements, both of which are beneficial.


Side Effects :

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.

Common side effects of Bortenat :

• Fatigue
• Anemia (low number of red blood cells)
• Nausea
• Low blood platelets
• Fever

Introduction :

Alphalan 5mg Tablet is used to treat cancer of ovaries and a type of cancer of bone marrow called multiple myeloma.  According to the doctor's judgement, it may also be used to treat other disorders.

Alphalan 5mg Tablet is given as an injection into veins by the doctor, but try to take it at the same time every day. Your doctor will determine the appropriate dosage and frequency of administration for you. This is based on the condition you are being treated for and is subject to change. You should follow your doctor's instructions to the letter. It can have potentially dangerous negative effects if taken improperly or in excess. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. It makes skin more sensitive towards sunlight, wear protective clothing or use sunscreen.

The most common side effects of this medicine include nausea, vomiting, anemia (low number of red blood cells) and hair loss. This medicine may reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. Inform your doctor if you observe signs of infections such as fever, chills, body ache or if you have unusual bruising or bleeding and  bleeding gums or blood in your urine or stool.

Before taking it, tell your doctor if you have bleeding, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.


Uses :

Ovarian cancer

Multiple myeloma


Benefits :

In Ovarian cancer :

The female reproductive organs that generate eggs are where ovarian cancer first appears (ovaries). This form of cancer is frequently found much later and can also be lethal. Usually, the pelvis and stomach are affected. Alphalan 5mg Tablet destroys cancer cells or inhibits their growth and also stops cancer cells from proliferating. Despite having certain side effects that could be irritating, the medication is beneficial. Thus, you should go over the advantages and disadvantages with your doctor. While receiving this medication, you should abstain from alcohol consumption and consume lots of water to stay hydrated.

In Multiple myeloma :

If you have multiple myeloma, your body is destroying bone faster than it is being replaced. This makes bones weak and painful and more likely to break. Alphalan 5mg Tablet may be prescribed along with other cancer treatments such as chemotherapy. It is an important part of your treatment and increases the survival rate of people with multiple myeloma. This medicine will kill the cancerous cells and prevent their further growth as well as spread to other parts of the body. Follow your doctor’s instructions carefully to get the most benefit. Supplements of calcium and Vitamin D3 are also effective and may be prescribed if you do not have high blood calcium levels.


Side Effects :

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.

Common side effects of Alphalan :

• Nausea
• Vomiting
• Stomatitis (Inflammation of the mouth)
• Anemia (low number of red blood cells)
• Hair loss
• Low blood platelets
• Diarrhea
• Decreased white blood cell count

Introduction :

Alkacel 50 Injection is used to treat cancer of ovaries and a type of cancer of bone marrow called multiple myeloma.  According to the doctor's judgement, it may also be used to treat other disorders.

Alkacel 50 Injection is given as an injection into veins by the doctor, but try to take it at the same time every day. Your doctor will determine the appropriate dosage and frequency of administration for you. This is based on the condition you are being treated for and is subject to change. You should follow your doctor's instructions to the letter. It can have potentially dangerous negative effects if taken improperly or in excess. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. It makes skin more sensitive towards sunlight, wear protective clothing or use sunscreen.

The most common side effects of this medicine include nausea, vomiting, anemia (low number of red blood cells) and hair loss. This medicine may reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. Inform your doctor if you observe signs of infections such as fever, chills, body ache or if you have unusual bruising or bleeding and  bleeding gums or blood in your urine or stool.

Before taking it, tell your doctor if you have bleeding, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.


Uses :

Ovarian cancer

Multiple myeloma


Benefits :

In Ovarian cancer :

The female reproductive organs that generate eggs are where ovarian cancer first appears (ovaries). This form of cancer is frequently found much later and can also be lethal. Usually, the pelvis and stomach are affected. Alkacel 50 Injection destroys cancer cells or inhibits their growth and also stops cancer cells from proliferating. Despite having certain side effects that could be irritating, the medication is beneficial. Thus, you should go over the advantages and disadvantages with your doctor. While receiving this medication, you should abstain from alcohol consumption and consume lots of water to stay hydrated.

In Multiple myeloma :

If you have multiple myeloma, your body is destroying bone faster than it is being replaced. This makes bones weak and painful and more likely to break. Alkacel 50 Injection may be prescribed along with other cancer treatments such as chemotherapy. It is an important part of your treatment and increases the survival rate of people with multiple myeloma. This medicine will kill the cancerous cells and prevent their further growth as well as spread to other parts of the body. Follow your doctor’s instructions carefully to get the most benefit. Supplements of calcium and Vitamin D3 are also effective and may be prescribed if you do not have high blood calcium levels.


Side Effects :

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.

Common side effects of Alkacel :

• Nausea
• Vomiting
• Stomatitis (Inflammation of the mouth)
• Anemia (low number of red blood cells)
• Hair loss
• Low blood platelets
• Diarrhea
• Decreased white blood cell count

Introduction To Thalix 50mg Capsule

Thalix 50mg Capsule belongs to the class of medications called immunomodulatory agents. It consists of the active ingredient Thalidomide. It is primarily indicated to treat patients recently diagnosed with multiple myeloma. Multiple myeloma is a type of cancer mainly affecting certain white blood cells called the plasma cell. These cells grow uncontrolled and accumulate in the bone marrow, damaging the bones and kidneys. It is also prescribed for treating moderate to severe new lesions in leprosy. Leprosy is a chronic disease that affects the skin and nerves and is caused by a bacteria called Mycobacterium leprae.

The common side effects that are likely to be associated with Thalix 50mg Capsule are sleepiness, headache, dizziness, rashes, pain, tiredness, constipation, nausea, impotence, loss of appetite, fever, depression, etc. Inform your doctor if these side effects disturb or persist in you.

Inform your medical professional if you are allergic to Thalix 50mg Capsule and its ingredients. Inform your doctor if you have blood clots, heart attack, neuropathy (pain in the hands or feet caused by nerve damage), slow heart rate, low and high blood pressure,  liver or kidney problems, viral infections like HIV, hepatitis B virus, and varicella zoster. Your physician will monitor the thyroid function before and during treatment with this medication. Stop taking Thalix 50mg Capsule and consult a doctor immediately if you have to think you are pregnant, if you have irregular periods, missed a period, have any change in menstrual bleeding, or if you had sex without using effective birth control. It is not recommended for adolescents and children under 18 years of age.

Uses Of Thalix 50mg Capsule

Adjunct to Dexamethasone for treating newly diagnosed multiple myeloma.

Treatment of moderate to severe leprosy.

Prevention of recurrence of skin lesions in leprosy.

Therapeutic Effects of Thalix 50mg Capsule

Thalix 50mg Capsule reduces inflammation and regulates the immune system. It works by enabling the body’s immune system and attacking the cancer cells. It stops the development of cancer cells by inhibiting the growth of blood vessels in tumors. It also modifies the production and activity of cytokines (growth factors) that are involved in the growth and metabolism of cancer cells.

More Information About Thalix 50mg Capsule

Store below  25°C.

Protect from light and moisture.

Keep this medicine out of reach of children.

Safety Advices For Thalix 50mg Capsule

Pregnancy 

Thalix 50mg Capsule is unsafe to use during pregnancy as it may cause birth defects and the death of the fetus. Inform your physician before taking this Capsule if you are pregnant or think you might be pregnant.

Breast Feeding 

Avoid breastfeeding while taking this medication as it is unknown if Thalix  50mg Capsule passes through breast milk. Consult your physician for advice before breastfeeding.

Lungs 

It is unknown whether Thalix 50mg capsule can be administered to lung failure patients. Consult your physician for more advice.

Liver 

Consult your physician before taking Thalix 50mg Capsule if you have liver problems.

Alcohol 

Avoid consuming alcohol while taking Thalix 50mg Capsule, as it may cause sleepiness.

Driving 

Do not drive or operate heavy machines if you experience side effects like dizziness, tiredness, sleepiness, or blurred vision.

Introduction :

Alphalan 2mg Tablet is used to treat cancer of ovaries and a type of cancer of bone marrow called multiple myeloma.  According to the doctor's judgement, it may also be used to treat other disorders.

Alphalan 2mg Tablet is given as an injection into veins by the doctor, but try to take it at the same time every day. Your doctor will determine the appropriate dosage and frequency of administration for you. This is based on the condition you are being treated for and is subject to change. You should follow your doctor's instructions to the letter. It can have potentially dangerous negative effects if taken improperly or in excess. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. It makes skin more sensitive towards sunlight, wear protective clothing or use sunscreen.

The most common side effects of this medicine include nausea, vomiting, anemia (low number of red blood cells) and hair loss. This medicine may reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. Inform your doctor if you observe signs of infections such as fever, chills, body ache or if you have unusual bruising or bleeding and  bleeding gums or blood in your urine or stool.

Before taking it, tell your doctor if you have bleeding, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.


Uses :

Ovarian cancer

Multiple myeloma


Benefits :

In Ovarian cancer :

The female reproductive organs that generate eggs are where ovarian cancer first appears (ovaries). This form of cancer is frequently found much later and can also be lethal. Usually, the pelvis and stomach are affected. Alphalan 2mg Tablet destroys cancer cells or inhibits their growth and also stops cancer cells from proliferating. Despite having certain side effects that could be irritating, the medication is beneficial. Thus, you should go over the advantages and disadvantages with your doctor. While receiving this medication, you should abstain from alcohol consumption and consume lots of water to stay hydrated.

In Multiple myeloma :

If you have multiple myeloma, your body is destroying bone faster than it is being replaced. This makes bones weak and painful and more likely to break. Alphalan 2mg Tablet may be prescribed along with other cancer treatments such as chemotherapy. It is an important part of your treatment and increases the survival rate of people with multiple myeloma. This medicine will kill the cancerous cells and prevent their further growth as well as spread to other parts of the body. Follow your doctor’s instructions carefully to get the most benefit. Supplements of calcium and Vitamin D3 are also effective and may be prescribed if you do not have high blood calcium levels.


Side Effects :

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.

Common side effects of Alphalan :

• Nausea
• Vomiting
• Stomatitis (Inflammation of the mouth)
• Anemia (low number of red blood cells)
• Hair loss
• Low blood platelets
• Diarrhea
• Decreased white blood cell count

Product Introduction

Thalix 100 Capsule is used in the treatment of multiple myeloma and lepra reaction. This medicine belongs to a group of medicines which affect how your immune system works.

Thalix 100 Capsule should be taken in the exact dose and duration recommended by the doctor. You should continue to take it as long as your doctor advises for it. The duration of treatment varies according to your need and response to treatment. Before taking Thalix 100 Capsule inform your doctor if you are suffering from any heart disease. Your doctor may get regular blood tests to check number of blood cells during your treatment. It may reduce white blood cells thereby, increasing the susceptibility to infections.

Common side effects of this medicine include nausea, rash, breathlessness, dizziness, edema (swelling), fatigue, and confusion. Let your doctor know if any of these side effects bothers you or get worse. They may be able to suggest ways to treat or prevent them. You should not drive or operate machinery as Thalix 100 Capsule may makes you feel sleepy. Women or men who are undergoing treatment should use effective contraception method and avoid pregnancy till doctor recommends it.

Uses Of Thalix Capsule

Multiple myeloma

Lepra reaction

Benefits Of Thalix Capsule

In Multiple myeloma

If you have multiple myeloma, your body is destroying bone faster than it is being replaced. This makes bones weak and painful and more likely to break. Thalix 100 Capsule may be prescribed along with other cancer treatments such as chemotherapy. It is an important part of your treatment and increases the survival rate of people with multiple myeloma. This medicine will kill the cancerous cells and prevent their further growth as well as spread to other parts of the body. Follow your doctor’s instructions carefully to get the most benefit. Supplements of calcium and Vitamin D3 are also effective and may be prescribed if you do not have high blood calcium levels.

Side Effects Of Thalix Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Thalix

Headache

Sleepiness

Nausea

Rash

Breathlessness

Dizziness

Edema (swelling)

Fatigue

Muscle weakness

Anxiety

Confusion

Constipation

Tremors

Sensory neuropathy

Change in body weight

Thromboembolism

Muscle pain

Anaphylactic reaction

Decreased potassium level in blood
Safety Advice

Alcohol

Thalix 100 Capsule may cause excessive drowsiness with alcohol.

Pregnancy

Thalix 100 Capsule is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding

Thalix 100 Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

Thalix 100 Capsule may cause side effects which could affect your ability to drive.

You may experience side effects, such as dizziness, tiredness, sleepiness or blurred vision with Thalix 100 Capsule and this may affect your ability to drive.

Kidney

Thalix 100 Capsule is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Thalix 100 Capsule may not be needed in these patients

Liver

Thalix 100 Capsule is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Thalix 100 Capsule may not be needed in these patients.