Corsantrum Technology

Ritlecitinib, a new experimental medication that falls under the class of selective ROS1/NTRK inhibitors, is a component of the targeted cancer treatment LuciRit 50mg. Designed for precision oncology, LuciRit targets genetic mutations found in specific tumors, making it an innovative choice in personalized cancer treatment. It is developed to treat patients with certain types of advanced or metastatic cancers, especially non-small cell lung cancer (NSCLC) that exhibits ROS1 gene rearrangements.

What is LuciRit 50mg?

LuciRit 50mg (Ritlectinib) is an oral targeted therapy drug developed to inhibit ROS1 and NTRK gene fusions in cancer cells. These gene fusions result in uncontrolled cell proliferation and tumor growth. Ritlectinib blocks these abnormal signaling pathways, thereby inhibiting tumor growth and spread. It is a selective, potent, and brain-penetrant tyrosine kinase inhibitor (TKI), effective in both systemic and intracranial disease.

How It Works / Mechanism of Action

• Ritlectinib acts as a tyrosine kinase inhibitor (TKI) specifically designed to target: ROS1 (c-ros oncogene 1)

• Tropomyosin receptor kinases, or TRK family of receptors (NRK1, NTRK2, and NTRK3)

Gene-fused tumors have aberrant activation of these receptors. Ritlectinib selectively binds to the ATP-binding pocket of the kinase domain of these fusion proteins and inhibits phosphorylation, which stops downstream signaling pathways like MAPK/ERK and PI3K/AKT—key drivers of cancer cell survival, proliferation, and metastasis. This leads to apoptosis (programmed cell death) and reduction in tumor burden.

How to Use / Indications

LuciRit 50mg is primarily indicated for:

• ROS1-positive metastatic non-small cell lung cancer (NSCLC)

• NTRK fusion-positive solid tumors (under clinical trials)

It may also be considered for cancers resistant to other ROS1 inhibitors like crizotinib, where Ritlectinib shows effectiveness against resistance mutations. This drug is typically prescribed after confirmation of gene fusions through next-generation sequencing (NGS) or FISH testing.

How to Take / Dosage

Recommended Dosage:

• The standard adult dose is Ritlectinib 50mg orally once or twice daily, based on physician discretion, body weight, and response.

Administration Instructions:

• Take with or without food.

• Swallow the tablet whole with water.

• Avoid crushing, chewing, or splitting.

• Take the medicine at the same time every day.

Other Dosage Forms / Strengths

LuciRit 100mg (for titration or dose adjustment) Investigational pediatric doses under clinical trials

Dose Adjustments May Be Required:

• In cases of liver or kidney impairment

• When combined with strong CYP3A4 inhibitors or inducers

• If adverse reactions or drug toxicity occur

Side EffectsCommon side effects include:

• Fatigue

• Constipation

• Nausea and vomiting

• Dizziness

• Diarrhea

• Increased liver enzymes (ALT, AST)

• Vision disturbances

Serious adverse effects:

• Hepatotoxicity (liver damage)

• QT prolongation (irregular heartbeat)

• CNS effects (headache, seizures)

• Myalgia or muscle weakness

• Pneumonitis (rare)

• Regular monitoring of liver function, ECG, and neurological status is recommended during treatment.

Introduction

Methylene Blue Injection Usp

What is methylene blue injection used for?

Methylene blue injection is used to treat a condition called methemoglobinemia. This condition occurs when the blood cannot deliver oxygen where it is needed in the body.

What is methylene blue benefits?

By scavenging free radicals and exerting potent anti-inflammatory effects, methylene blue helps protect your cells from oxidative damage and prevents the development of chronic diseases that stem from inflammation.

Does methylene blue have side effects?

This medicine may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. For at least 24 hours after treatment with methylene blue, avoid exposure to sunlight or tanning beds.

Is it good to take methylene blue?

Recent studies suggest that methylene blue, at low doses, can act as a powerful antioxidant and improve mitochondrial function and the ability for our cells to produce energy. That's why many people have been using it as a brain-boosting, nootropic supplement.

Side Effects

•    Agitation.
•    bluish-colored lips, fingernails
•    chest tightness.
•    confusion.
•    cough.
•    dark urine.
•    diarrhea.
•    difficulty breathing. 

Product Introduction

Albuzor 5 g Solution for Infusion is used to treat blood volume loss. It works by replacing the body fluids lost due to excessive trauma, bleeding, surgery, or kidney dialysis. Thus, it is helpful in treating low blood albumin levels.

Albuzor 5 g Solution for Infusion must be administered under the supervision of a healthcare professional. You should not take it if you have any known allergies to this injection. Before taking it, inform the doctor you are suffering from any severe heart disease.

Your doctor may check your blood pressure and ask you to get regular blood tests done while you are using this injection. The most common side effects include flushing, nausea, vomiting, chills, and fever.

Inform your doctor if you are pregnant or breastfeeding. Let your doctor also know if you have any kidney diseases as a dose adjustment may be required. This injection is safe to use in patients suffering from liver diseases.

Uses Of Albuzor Injection

Short term fluid replacement after trauma

Benefits Of Albuzor Injection

In Short term fluid replacement after trauma

Albuzor 5 g Solution for Infusion contains albumin, a protein that protects the patient from dehydration and electrolyte disorders after any trauma or injury. Appropriate fluid replacement is very essential to restore normal brain activity and other vital functions of the body to promote healing as well as speedy recovery.

Side Effects Of Albuzor Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

common side effects of Albuzor

Vomiting

Flushing (sense of warmth in the face, ears, neck and trunk)

Fever

Nausea

Chills

Hives

Slow heart rate

How To Use Albuzor Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Albuzor Injection Works

Albuzor 5 g Solution for Infusion contains human albumin, a natural protein in blood. It works by replacing the blood or body fluids lost due to excessive bleeding, surgery, or kidney dialysis.

Safety Advice

Alcohol

It is not known whether it is safe to consume alcohol with Albuzor 5 g Solution for Infusion.

Pregnancy

Albuzor 5 g Solution for Infusion may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

Breast feeding

Information regarding the use of Albuzor 5 g Solution for Infusion during breastfeeding is not available.

Driving

Albuzor 5 g Solution for Infusion does not usually affect your ability to drive.

Kidney

Albuzor 5 g Solution for Infusion should be used with caution in patients with kidney disease. Dose adjustment of Albuzor 5 g Solution for Infusion may be needed.

Liver

Albuzor 5 g Solution for Infusion is safe to use in patients with liver disease. No dose adjustment of Albuzor 5 g Solution for Infusion is recommended.

Product Introduction

Invega Sustenna 150mg Injection is used in the treatment of schizophrenia (a mental disorder that can result in hallucinations or delusions and also adversely affects a person’s ability to think and behave) and mania.

Invega Sustenna 150mg Injection is given under the supervision of a healthcare professional. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. This medication should not be stopped suddenly without talking to your doctor as it may worsen your symptoms. However, discontinue this medicine immediately if you experience neuroleptic malignant syndrome (NMS), characterized by fever, muscle rigidity, and altered consciousness.

Some common side effects of this medicine include injection site reactions (pain, swelling, redness), nystagmus (involuntary eye movement), and tremor. It also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you.

You should be cautious if you are using this medicine as it may increase the risk of developing diabetes, so it is better to monitor glucose regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts while taking this medicine.

There is a Patient Support Program/Patient Assistance Program available in India for this medicine, being managed by Tata 1mg. Please contact your prescribing doctor to know more about the same. You may also call on (1800-102-1618) for more details.

Uses Of Invega Sustenna Injection

Schizophrenia

Mania

Benefits Of Invega Sustenna Injection

In Schizophrenia

Common side effects of Invega Sustenna

Abnormal involuntary movements

Dizziness

Injection site reactions (pain, swelling, redness)

Nystagmus (involuntary eye movement)

Sleepiness

Tremors

Safety Advice

Alcohol

It is unsafe to consume alcohol with Invega Sustenna 150mg Injection.

Pregnancy

Invega Sustenna 150mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

Breast feeding

Invega Sustenna 150mg Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

Invega Sustenna 150mg Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

Invega Sustenna 150mg Injection should be used with caution in patients with kidney disease. Dose adjustment of Invega Sustenna 150mg Injection may be needed.

Use of Invega Sustenna 150mg Injection is not recommended in patients with end-stage kidney disease.

Liver

Invega Sustenna 150mg Injection should be used with caution in patients with severe liver disease. Dose adjustment of Invega Sustenna 150mg Injection may be needed.

Limited information is available on the use of Invega Sustenna 150mg Injection in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.